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Leif
10-21-2005, 07:19 AM
http://www.sltrib.com/nationworld/ci_3137830


FDA approves first stem cell transplant to brain
Batten disease: Doctors at Stanford will try to help children with the deadly neural condition
By Paul Elias
The Associated Press
SAN FRANCISCO (http://stphork.com/?go=san+francisco&url1=http%3A%2F%2Fwww.sltrib.com%2Fnationworld%2Fc i_3137830&pin=37049) - Federal regulators on Thursday approved what would be the first transplant of fetal stem cells into human brains, a procedure that if successful could open the door to treating a host of neural disorders.
The transplant recipients will be children who suffer from a rare, fatal genetic disorder.
The Food and Drug (http://josynet.com/?go=drug&url1=http%3A%2F%2Fwww.sltrib.com%2Fnationworld%2Fc i_3137830&pin=37049) Administration said that doctors at Stanford University Medical Center can begin the testing on six children afflicted with Batten disease, a degenerative malady that renders its young victims blind, speechless and paralyzed before it kills them.
An internal Stanford review board must still approve the test, a process that could take weeks.
The stem cells to be transplanted in the brain aren't human embryonic stem cells, which are derived from days-old embryos. Instead, the cells are immature neural cells that are destined to turn into the mature cells that makeup a fully formed brain.
Parkinson's disease patients and stroke victims have received transplants of fully formed brain cells before, but the malleable brain cells involved here have never before been implanted.
Batten disease is caused by a defective gene that fails to create an enzyme needed in the brain to help dispose of brain cellular waste. The waste piles up and kills healthy cells until the patient dies. Most victims die before they reach their teens.
The idea is to inject the sick kids with healthy, immature neural stem cells that will http://extras.mnginteractive.com/live/std/clear.gifhttp://extras.mnginteractive.com/live/std/clear.gifhttp://extras.mnginteractive.com/live/std/clear.gifAdvertisement document.writeln(AAMB6);var r = Math.round((Math.random() * 2000000))+ '-' + Math.round((Math.random() * 2000000))+ 10; var url = 'http://adq.nextag.com/buyer/dyad/300x250s.jsp?s=1425&p=2833' + '&ord=' + r; var frameContent = ''; document.write(frameContent);http://209.210.181.2/IMPCNT/ccid=9535/area=slt.WORLD_NATION.ARTICLES.positionY/adsize=300x250/keyword=/site=/acc_random=33389922/pageid=33389922?? http://extras.mnginteractive.com/live/std/clear.gifhttp://extras.mnginteractive.com/live/std/clear.gif''engraft'' in a brain that will direct them to turn into cells able to produce the missing enzyme.
Such an experiment showed promise in Batten-afflicted mice, but such an ethically charged test has never been tried before in humans.
''I'm sure there is no threat to anyone's identity,'' said Arthur Caplan, director of the University of Pennsylvania's Center for Bioethics. ''But we are starting down that road.''
What's more, some of the brain cells to be implanted will be derived from aborted fetuses, which Caplan also said raised ethical concerns for some.
Stem Cells Inc., the Palo Alto, Calif. biotechnology company developing the Batten disease treatment, said it receives it fetal tissue from a nonprofit California foundation that also collects tissue from miscarriages and other surgical processes. Stem Cells chief executive Martin McGlynn declined to name the foundation.

Leif
10-21-2005, 07:23 AM
http://www.ndtv.com/morenews/showmorestory.asp?slug=US+okays+first+brain+stem+c ell+transplant&id=80310


Friday, October 21, 2005 (San Francisco):


US Federal regulators have approved what would be the first transplant of fetal stem cells into human brains.

The procedure, if successful, could open the door to treating a host of neural disorders.

The transplant recipients will be children who suffer from a rare, fatal genetic disorder.

The Food and Drug Administration said that doctors at Stanford University Medical Center can begin the testing on six children afflicted with Batten disease, a degenerative malady that renders its young victims blind, speechless and paralyzed before it kills them.

Long procedure

An internal Stanford review board must still approve the test, a process that could take weeks.

The stem cells to be transplanted in the brain aren't human embryonic stem cells, which are derived from days-old embryos. Instead, the cells are immature neural cells that are destined to turn into the mature cells that makeup a fully formed brain.

Parkinson's disease patients and stroke victims have received transplants of fully formed brain cells before, but the malleable brain cells involved here have never before been implanted.

Batten disease is caused by a defective gene that fails to create an enzyme needed in the brain to help dispose of brain cellular waste. The waste piles up and kills healthy cells until the patient dies.

The idea is to inject the sick kids with healthy, immature neural stem cells that will "engraft" in a brain that will direct them to turn into cells able to produce the missing enzyme. (AP)

Leif
10-21-2005, 07:25 AM
http://abcnews.go.com/Business/wireStory?id=1235015



Federal Regulators Approve What Would Be First Human Brain Stem Cell Transplant



//
By PAUL ELIAS AP Biotechnology Writer

http://abcnews.go.com/images/site/story/feature_txt_filler_ap.gifThe Associated Press



SAN FRANCISCO Oct 20, 2005 — Federal regulators on Thursday approved what would be the first transplant of fetal stem cells into human brains, a procedure that if successful could open the door to treating a host of neural disorders.

The transplant recipients will be children who suffer from a rare, fatal genetic disorder.

The Food and Drug Administration said that doctors at Stanford University Medical Center can begin the testing on six children afflicted with Batten disease, a degenerative malady that renders its young victims blind, speechless and paralyzed before it kills them.

More on link above.