View Full Version : Stem cell heart cure to be tested

10-11-2005, 03:27 PM

Using stem cells to treat heart start to be quite common these days :)

Last Updated: Tuesday, 11 October 2005, 17:00 GMT 18:00 UK http://newsimg.bbc.co.uk/shared/img/o.gif

Stem cell heart cure to be tested

http://newsimg.bbc.co.uk/media/images/40892000/jpg/_40892360_lab203.jpg Different therapies will be tested

Doctors have launched a trial to test whether heart disease can be treated using a patient's own stem cells.

The study, at Barts and the London NHS Trust, is funded by a charity set up by a man who underwent stem cell treatment for his heart condition in Germany.

The aim will be to determine whether adult stem cells taken from bone marrow can repair damaged heart muscle.

In total, 700 patients will take part in the study, which will test three different forms of stem cell therapy.

http://newsimg.bbc.co.uk/shared/img/o.gifSTUDY VOLUNTEER
Gerry Sherrick, 71, a retired taxi driver from Essex has had two heart attacks and two triple bypass operations.
He said: "My heart has become steadily weaker over the years. I now struggle to do many of the things I could do before. Mundane tasks like getting washed, eating and even lifting up a newspaper can leave me feeling completely exhausted.
"I have my good days but on others it can be a struggle just to get out of bed."

The first part of the study will involve 300 patients whose hearts are failing because of heart disease or a previous heart attack.

A second arm will involve 200 patients whose hearts are failing specifically because of dilated cardiomyopathy - a heart muscle disorder.

And a final element will involve 200 patients who have just had a heart attack.

Some patients will have stem cells extracted from bone marrow in their hip and injected into their major coronary arteries or directly into their heart.

Others will receive injections of growth factor drugs to try to cause stem cells to spill out of their bone marrow and into their blood without the need for the operation.

Huge potential

Lead researcher Dr Anthony Mathur said: "This is one of the biggest and most comprehensive trials of its kind in the world.

http://newsimg.bbc.co.uk/media/images/40892000/jpg/_40892372_rosenberg203.jpg Ian Rosenberg has benefitted from stem cell therapy

"Our studies will tell us if adult stem cells in bone marrow can repair damaged hearts and if so how these cells should be administered to patients.

"There is growing evidence to suggest that stem cells may benefit people with serious heart conditions, such as heart failure or those who have had heart attacks."

Stem cells are the body's master cells, with the ability to turn into almost any type of cell in the body.

Dr Mathur said harnessing the cell's potential to repair damaged heart muscle good be good news for the 2.7m people with heart disease in the UK.

He said: "If proven to work, these cells could revolutionise the way we treat heart disease and could transform the lives of millions of people not only in the UK but around the world."

The work is being funded by a new charity, the Heart Cells Foundation, set up by Ian Rosenberg.

Two years ago doctors told Mr Rosenberg his heart disease was so severe that he had just a couple of months to live.

He travelled to Germany, were stem cells were injected into his heart.

"Within a matter of months, I was able to do things I could only dream of doing before, such as walking up and down stairs or playing golf," he said.

"Stem cell therapy has given me years I never thought I would have.

"I set up the Heart Cells Foundation so that others may benefit from this new and exciting science."

So far the charity has raised £1m to fund the Barts' research. However, another £5m will be needed over the next four years.

Peter Weissberg, of the British Heart Foundation, said stem cell therapy had the potential to revolutionise the treatment of heart disease. However, he said much work was needed to determine whether the therapy was safe as well as effective. People interested in taking part in the clinical trial can get more information by calling 020 8983 2216, or by emailing laura.roberts@bartsandthelondon.nhs.uk.

10-12-2005, 12:52 PM

Terminally-ill Gordon Mountain could become one of the first people in Britain to be given pioneering life-saving treatment.

The survivor of four heart attacks has been told he is suitable to take part in ground-breaking clinical trials.

The 66-year-old, who has congestive heart failure, is set to take part in a stem cell project led by Barts Hospital, in London, and The London NHS Trust. The £1m stem cell trials were launched in London today. They are funded by the Heart Cells Foundation.

This organisation was founded by Ian Rosenberg, who received stem cell treatment in Germany. Mr Mountain, of Foster Close, Timberland, near Metheringham, hopes to be one of the "guinea pigs" who will be given a new lease of life by having the treatment.

More on link above.

10-13-2005, 01:59 PM

By Ian Rosenberg for CNN
Thursday, October 13, 2005 Posted: 1415 GMT (2215 HKT)

LONDON, England (CNN) -- Two years ago Ian Rosenberg, from London, was told he had two and a half months to live. The 59-year-old had pioneering stem cell treatment which enabled his heart to repair damaged tissue.
I used to be incredibly active. I climbed mountains, skied and played golf. Then when I was 38, I had a heart attack, which dramatically changed my life. Two years later, in 1987, I had surgery to remove some of the scar tissue from my heart. After my heart attack, and even after the scars were removed, I became increasingly unwell and by 2003, I couldn't even walk up two steps.

I'd had implantable defibrillators in my chest for nine years and every time they went off, they were weakening my heart even further. Plus, the medication I was taking was losing its punch. It was only when I fainted one day they eventually found my heart was in such bad shape that they told me I had only two and a half months to live. My heart was giving up and it needed to be strengthened.

I had heard about stem cells but most or all of the cardiologists I met didn't know anything about it. I had read about one who lived in Monte Carlo. I made enquires and was told that while the treatment wasn't light years away, it was still being tested.

In the end, I said, "Why don't you test it on me," and they agreed. I've had stem cell treatment three times since July 2003. I have it at the Johann Wolfgang Goethe-University Hospital in Frankfurt -- it's not a swanky hospital but it is Frankfurt's biggest teaching hospital.

More on link above.