View Full Version : Increase in Stem Cell Subtype Indicates Better Survival Rate in Acute Lung Injury

10-04-2005, 05:13 AM

04 Oct 2005

Researchers found that an increase in the number of a certain type of stem cell in patient's blood was associated with a much improved survival rate for those hit by a devastating cause of respiratory failure, acute lung injury (ALI).

According to the authors, the improved survival rate among 45 patients with ALI correlated with higher colony counts of a stem cell subtype called endothelial progenitor cells (EPCs). Patients with ALI, which constitutes a very serious illness, usually require ventilator support, and face a high death rate.

The researchers noted that repair of damaged endothelium--the layer of flat cells that lines the heart, blood and lymph vessels, as well as some body cavities--is important in recovering from acute lung injury. In animal models, bone marrow-derived EPCs differentiate into mature endothelium and assist in repairing a damaged vascular system.

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