Wise Young
07-22-2002, 05:50 PM
• Filipovic R, Rakic S and Zecevic N (2002). Expression of Golli proteins in adult human brain and multiple sclerosis lesions. J Neuroimmunol. 127 (1-2): 1-12. Summary: It has been suggested that Golli proteins, structurally related to myelin basic proteins (MBPs), have a role in autoimmune processes. We studied the expression of these proteins in multiple sclerosis (MS) and determined that the number of Golli-immunoreactive (ir) cells was significantly higher around lesions of chronic MS than in control white matter. Golli proteins were expressed in the adult oligodendrocyte precursor cells (OPCs), activated microglia/macrophages, and some demyelinated axons around MS lesions. Their expression in adult OPCs indicates remyelination attempts, whereas the expression in the subpopulation of microglia/macrophages suggests roles in the immune processes of MS. In addition, Golli proteins may be markers of axonal transection, which is characteristic for MS. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12044969> Department of Neuroscience, University of Connecticut Medical School, 263 Farmington Ave., Farmington, CT 06030-3401, USA.