Wise Young
01-01-2002, 02:00 PM
• Filippi M, Rovaris M, Rocca MA, Sormani MP, Wolinsky JS and Comi G (2001). Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes". Neurology. 57 (4): 731-3. Summary: The authors evaluated whether glatiramer acetate (GA) modifies the severity of tissue damage in 1,722 new lesions from 239 patients with MS enrolled in a placebo-controlled trial monitored with monthly cerebral MRI. The percentage of new lesions that evolved into "black holes" was lower in GA-treated than in placebo patients on scans at 7 (18.9 and 26.3%; p = 0.04) and 8 (15.6 and 31.4%; p = 0.002) months after lesion appearance. GA has a favorable effect on tissue disruption in MS lesions once they are formed. <http://www.neurology.org/cgi/content/full/57/4/731
http://www.neurology.org/cgi/content/abstract/57/4/731
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11524494> Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy. filppi.massimo@hsr.it
http://www.neurology.org/cgi/content/abstract/57/4/731
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11524494> Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy. filppi.massimo@hsr.it