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Max
06-14-2002, 11:52 AM
Spray in trials to treat heroin addicts
Terry Macalister
Friday June 14, 2002
The Guardian

GW Pharmaceuticals, the small British company at the forefront of developing cannabis medicines, is to have its innovative drug-dispensing equipment used in trials with registered heroin addicts.

The National Addiction Centre, with the approval of the Home Office, is to use GW's advanced dispensing system in trials with 30,000 registered patients receiving methadone and diamorphine.

The GW device allows users to take approved opiates via a spray under the tongue rather than having to inject them using needles. The ADS device electronically controls the amount of drugs dispensed to users at any one time and, therefore, reduces the amount of supervision needed at medical centres.

"We are looking for a major increase in safety and effectiveness of treatment alongside a dramatic increase in the number of patients being treated - without any increase in the cost per patient," said John Strang, director of the National Addiction Centre.

GW's chairman, Geoffrey Guy, said he hoped to meet a target to provide its dispenser to 60,000 addicts within three years. There are estimated to be 250,000 regular heroin users in Britain but only 30,000 are receiving methadone prescriptions and many of these are being handed out in large weekly instalments. This method is thought to be responsible for a growing number of deaths by overdose.

Meanwhile, GW is planning to increase the number of trials it is running to discover the medical benefits of cannabis from seven to nine.

Later this year it could have nearly 1,000 patients trialling cannabis-based treatments for multiple sclerosis, spinal cord injury and cancer pain. It will submit its findings for approval early next year and hopes to obtain a licence soon after, while similar moves are afoot in mainland Europe and Canada.

To meet the growing needs of its trials, the company has signed a contract with an unnamed third party to produce 60 tonnes of cannabis a year. GW already grows 30 tonnes under greenhouses in secret locations in the south of England.

GW reported a loss in line with its budget of £5.3m for the six months to March 31, compared with a £2m deficit for the same period last year.


Guardian Unlimited © Guardian Newspapers Limited 2002

Max
06-14-2002, 01:14 PM
Cannabis, methadone lift for GW

by Malcolm Withers, Evening Standard

GW PHARMACEUTICALS, the only company in Britain that holds a licence to develop cannabis-based medicines, is to increase the number of trials it is running to discover the medical benefits of the drug. It also co-operating with the National Addiction Centre to produce a revolutionary tamper-proof methadone dispenser for heroin addicts.

With up to 250,000 heroin addicts in Britain the Government is concerned about rising drug-related crime. One of the treatments for heroin addiction is methadone and currently 30,000 are being treated with it. However, the drug can be misused unless it is strictly administered. GWP's telecoms-based dispenser is claimed to do this.

GWP today added two new cannabis trials to its existing seven, taking the number of patients involved to 650. They will use cannabis-based treatments for multiple sclerosis, spinal cord injury, neuropathic pain and cancer pain.

Patients involved in the trials at hospitals throughout Britain will receive the drugs via a spray under the tongue. To check their effectiveness, some patients receive placebos. Earlier trials of the drug with 109 patients led to 88 completing the acute phase and 86 of them wanting to continue with the drug because it eased pain.

There is growing evidence that cannabis provides pain relief and the global market for treatments based on the drug could be worth £8bn a year. GW Pharma chairman Dr Geoffrey Guy believes some of the drugs will be submitted to the Medicines Control Agency for approval next year and they could be commercially marketed in Britain by 2004. Trials are also going ahead in other European countries.

The company's secret greenhouses 'somewhere in the South of England' produce six crops of cannabis a year weighing a total of 30 tonnes. A contract has just been signed with an unnamed third party to double production. The greenhouses are surrounded by electric fences and are under round-the-clock surveillance. The 102-strong workforce tends to be over the age of 40 and undergoes strict security checks.

In the six months to March, GW Pharma's losses amounted to £5.3m with research and development costing £5.1m. The group has cash reserves of £21.1m. Shares in GWP added 1p to 112p.



© Associated Newspapers Ltd., 13 June 2002
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