View Full Version : Do you have neuropathic pain, take amitriptyline and drink coffee?
01-11-2002, 02:06 AM
Esser, et al. (http://carecure.org/forum/showpost.php?p=131643) recently reported that caffeine (an adenosine receptor antagonist) blocks the beneficial effects of amitriptyline in a sciatic ligation model of neuropathic pain in rats. Animal studies have shown that adenosine has a long-lasting effect on neuropathic pain. Likewise, Eisenach, et al. (http://carecure.org/forum/showpost.php?p=130870) showed that intrathecal adenosine reduces hyperalgesia associated with sciatic nerve ligation and intradermal capsaicin injections in human volunteers. Therefore, the effects of amitriptyline may be partly mediated by adenosine. I am wondering how many people here have neuropathic pain, take amitriptyline, and/or drink coffee. Neuropathic pain, for the purposes of this poll, is abnormal pain sensations localized below the injury site, often characterized as burning, aching, freezing, vibratory.
01-11-2002, 11:19 AM
I do have neuropathic pain, but I don't take anything for it. I only occasionally drink coffee, but I do drink caffeinated soda or iced tea. So far, my pain is generally tolerable, especially if I'm concentrating on something other than the pain.
"We are not brave because we are free. We are free because we are brave." ~ Rich Ward (Stuck Mojo / Sick Speed)
Yesterday, I answered "I have neuropathic pain, take amitryptyline, and drink coffee." As of today, I'm sticking to decaf. Hopefully, there will be an improvement. http://sci.rutgers.edu/forum/images/smilies/smile.gif
Hey, I'm here to learn. Information like this can make a big difference. Thanks for posting it.
My only caffeine intake is a little iced tea at dinner. No amitryptiline (actuallly, I'm not on anything for pain right now, as we've run out of things to try.)