Do you have neuropathic pain, take amitriptyline and drink coffee?

[Wise Young]

Esser, et al. (http://carecure.org/forum/showpost.php?p=131643) recently reported that caffeine (an adenosine receptor antagonist) blocks the beneficial effects of amitriptyline in a sciatic ligation model of neuropathic pain in rats. Animal studies have shown that adenosine has a long-lasting effect on neuropathic pain. Likewise, Eisenach, et al. (http://carecure.org/forum/showpost.php?p=130870) showed that intrathecal adenosine reduces hyperalgesia associated with sciatic nerve ligation and intradermal capsaicin injections in human volunteers. Therefore, the effects of amitriptyline may be partly mediated by adenosine. I am wondering how many people here have neuropathic pain, take amitriptyline, and/or drink coffee. Neuropathic pain, for the purposes of this poll, is abnormal pain sensations localized below the injury site, often characterized as burning, aching, freezing, vibratory.

[Scorpion]

I do have neuropathic pain, but I don't take anything for it. I only occasionally drink coffee, but I do drink caffeinated soda or iced tea. So far, my pain is generally tolerable, especially if I'm concentrating on something other than the pain.

~Rus

"We are not brave because we are free. We are free because we are brave." ~ Rich Ward (Stuck Mojo / Sick Speed)

[rtr]

Yesterday, I answered "I have neuropathic pain, take amitryptyline, and drink coffee." As of today, I'm sticking to decaf. Hopefully, there will be an improvement. http://sci.rutgers.edu/forum/images/smilies/smile.gif

Hey, I'm here to learn. Information like this can make a big difference. Thanks for posting it.

[alan]

My only caffeine intake is a little iced tea at dinner. No amitryptiline (actuallly, I'm not on anything for pain right now, as we've run out of things to try.)