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Wise Young
10-02-2001, 04:54 PM
Chronic Pain in SCI

Pain is a widespread problem after spinal cord injury and can be a major cause of suffering and reduced quality of life. The University of Washington received funding from the National Institutes of Health (NIH) to conduct two studies relating to pain and SCI. The principal investigator is Diana Cardenas, MD.

The first study involves completing a questionnaire about pain intensity, location, and treatment as well as demographic variables such as age, sex, years since injury, level of injury, vocational status, etc.

The second study is investigating treatment of chronic pain in individuals with SCI. Participants are randomly assigned to one of two groups and receive a six-week trial of either a medication known to help with chronic pain or a placebo (a substance that is not expected to help with pain). Subjects will not know whether they are taking the medication or the placebo until after they have completed the study.

If you are interested in participating in either study, please contact: Cathy Warms, MN, ARNP at 206-616-8568 and leave your name and number. Subjects who complete and return the questionnaire will receive $20. To participate in the drug study, subjects must be between the ages of 18 and 65 and at least 6 months post-SCI with pain of at least 3 months' duration, and be willing to drive to Seattle weekly and take a medication once a day for 6 weeks. Payment for the drug study (including several phone interviews in addition to the six-week trial) will be $100.

More information about these studies can be found at the Study of Chronic Pain website.
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The SCI Project

The spinal cord injury project has two major studies:


1. Study 1: Survey of Chronic Pain in Spinal Cord Injury
To date, 525 surveys have been returned. Seventy eight percent of these respondents report that they are currently experiencing chronic pain.

2. Study 2: Management of Chronic Pain in Spinal Cord Injury
This study is a placebo-controlled drug trial investigating the effectiveness of amitriptyline for pain associated with spinal cord injury. To date, 63 participants have been enrolled.

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Study of Chronic Pain Management
Published Results

1. Ehde, D.M., Czerniecki, J.M., Smith, D.G., Jensen, M.P., and Robinson, L.R. (1998). Chronic pain following lower limb amputation. Archives of Physical Medicine and Rehabilitation, 79, 1172-1173.

2. Schwartz, L., Engel, J.M., and Jensen, M.P. (1998). Pain complaints in the cerebral palsy population. Archives of Physical Medicine and Rehabilitation, 79, 1173.

3. Schwartz, L., Engel, J.M., and Jensen, M.P. (1999). Pain in persons with cerebral palsy. Archives of Physical Medicine and Rehabilitation, 80 (10), 1243-1246.

4. Smith, D., Ehde, D., Legro, M., Reiber, G., DelAguila, M., and Boone, D. (1999). Phantom limb, residual limb, and back pain after lower extremity amputations. Clinical Orthopaedics and Related Research, 361, 29-38.

5. Turner, J., Cardenas, D. (1999). Chronic pain problems in individuals with spinal cord injuries. Seminars in Clinical Neuropsychiatry, 4, 186-194.

6. Dalyan, M., Cardenas, D.D., and Gerard, B. (1999). Upper extremity pain after spinal cord injury. Spinal Cord, 37, 191-195.

7. Cardenas, D. (1999). Current concepts of rehabilitation of spinal cord injury patients. Spine: State of the Art Reviews, 13(3), 575-585.

8. Schwartz, L. and Ehde, D.M. (2000). Couples and chronic pain. In K.B. Schmaling & T.G. Sher (Eds.), The Psychology of Couples and Illness. Washington, DC: American Psychological Association Books.

9. Engel, J.M. (2000). Pain experiences in adults with cerebral palsy. Washington Occupational Therapy Association Newsletter, 57(2), 1, 6-7.