Wise Young
08-21-2001, 07:47 PM
Magnetic Stimulation of the Human Nervous System
This study is currently recruiting patients.
Sponsored by
National Institute of Neurological Disorders and Stroke (NINDS)
Purpose
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique to gather information about brain function. It is very useful when studying the areas of the brain related to motor activity (motor cortex, corticospinal tract, spinal cord and nerve roots). The procedure is conducted by transmitting a magnetic signal into the brain to stimulate an area of the body. Electrodes (small pieces of metal taped to areas of the body) are used in order to measure electrical activity. A magnetic signal is sent from a metal instrument held close to the patient's head, to an area of the brain responsible for motor activity of a certain area of the body. The electrodes pick up and record the electrical activity in the muscles.
This study will employ the use of TMS to diagnose neurological disorders that affect the motor cortex or the corticospinal tract. Normal subjects are sometimes studied to investigate normal activity of the nervous system and to train doctors in clinical neurophysiology and electrodiagnostic medicine at the National Institutes of Health (NIH).
Condition
Demyelinating Disease
Healthy
Lysosomal Storage Disease
Motor Neuron Disease
Movement Disorder
MEDLINEplusrelated topics:DegenerativeNerveDiseases; MovementDisorders; NeurologicDiseases(General)
Study Type:Natural History
Official Title:Stimulation of the Human Central and Peripheral Nervous System with a Magnetic Stimulator
Further Study Details:
This protocol outlines the use of magnetic stimulation as a diagnostic tool in patients with suspected dysfunction of central motor pathways or nerve roots and as a tool to investigate normal mechanisms that activate spinal motorneurons. The magnetic stimuli are to be given as single or paired pulses at low repetition rates.
Transcranial magnetic stimulation has been used for diagnosis of neurologic disorders since 1987. The principles of magnetic stimulation and its use for diagnosis are described in current textbooks of clinical neurophysiology as a routine procedure and should be included in the training program for fellows in clinical neurophysiology and electrodiagnostic medicine at NIH.
Eligibility
Genders Eligible for Study: Both
Criteria
Adult patients with weakness or motor dysfunction. Children and adolescents with corticospinal tract signs. Normal volunteers, adults.
Normal volunteers, children.
Women must not be pregnant.
Subjects must not have implanted devices: pacemakers, medication pumps or defibrillators. Subjects must not have metal in the cranium except the mouth. Subjects must not have intracardiac lines. Normal subjects must not have a history of seizures.
Location and Contact Information
Maryland
National Institute of Neurological Disorders and Stroke (NINDS),9000 Rockville Pike Bethesda, Maryland, 20892, United States;Recruiting
PRPL 1-800-411-1222 prpl@mail.cc.nih.gov
More Information
Detailed Web Page
Publications
Eisen. 1990. Clinical experience with transcranial magnetic stimulation, Muscle Nerve, Vol. 13, p. 995
Wassermann. 1996. Responses to paired transcranial magnetic stimuli in resting, active, and recently activated muscles, Exp Brain Res, Vol. 109, p. 158
Muller. 1991. Magnetic stimulation of motor cortex and nerve roots in children Maturation of cortico-motoneuronal projections, Electroencephalogr Clin Neurophysiol, Vol. 81, p. 63
Study ID Numbers 98-N-0065
NLM Identifier NCT00001780
Date study startedFebruary 10, 1998
Record last reviewed November 16, 2000
Last Updated November 16, 2000
This study is currently recruiting patients.
Sponsored by
National Institute of Neurological Disorders and Stroke (NINDS)
Purpose
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique to gather information about brain function. It is very useful when studying the areas of the brain related to motor activity (motor cortex, corticospinal tract, spinal cord and nerve roots). The procedure is conducted by transmitting a magnetic signal into the brain to stimulate an area of the body. Electrodes (small pieces of metal taped to areas of the body) are used in order to measure electrical activity. A magnetic signal is sent from a metal instrument held close to the patient's head, to an area of the brain responsible for motor activity of a certain area of the body. The electrodes pick up and record the electrical activity in the muscles.
This study will employ the use of TMS to diagnose neurological disorders that affect the motor cortex or the corticospinal tract. Normal subjects are sometimes studied to investigate normal activity of the nervous system and to train doctors in clinical neurophysiology and electrodiagnostic medicine at the National Institutes of Health (NIH).
Condition
Demyelinating Disease
Healthy
Lysosomal Storage Disease
Motor Neuron Disease
Movement Disorder
MEDLINEplusrelated topics:DegenerativeNerveDiseases; MovementDisorders; NeurologicDiseases(General)
Study Type:Natural History
Official Title:Stimulation of the Human Central and Peripheral Nervous System with a Magnetic Stimulator
Further Study Details:
This protocol outlines the use of magnetic stimulation as a diagnostic tool in patients with suspected dysfunction of central motor pathways or nerve roots and as a tool to investigate normal mechanisms that activate spinal motorneurons. The magnetic stimuli are to be given as single or paired pulses at low repetition rates.
Transcranial magnetic stimulation has been used for diagnosis of neurologic disorders since 1987. The principles of magnetic stimulation and its use for diagnosis are described in current textbooks of clinical neurophysiology as a routine procedure and should be included in the training program for fellows in clinical neurophysiology and electrodiagnostic medicine at NIH.
Eligibility
Genders Eligible for Study: Both
Criteria
Adult patients with weakness or motor dysfunction. Children and adolescents with corticospinal tract signs. Normal volunteers, adults.
Normal volunteers, children.
Women must not be pregnant.
Subjects must not have implanted devices: pacemakers, medication pumps or defibrillators. Subjects must not have metal in the cranium except the mouth. Subjects must not have intracardiac lines. Normal subjects must not have a history of seizures.
Location and Contact Information
Maryland
National Institute of Neurological Disorders and Stroke (NINDS),9000 Rockville Pike Bethesda, Maryland, 20892, United States;Recruiting
PRPL 1-800-411-1222 prpl@mail.cc.nih.gov
More Information
Detailed Web Page
Publications
Eisen. 1990. Clinical experience with transcranial magnetic stimulation, Muscle Nerve, Vol. 13, p. 995
Wassermann. 1996. Responses to paired transcranial magnetic stimuli in resting, active, and recently activated muscles, Exp Brain Res, Vol. 109, p. 158
Muller. 1991. Magnetic stimulation of motor cortex and nerve roots in children Maturation of cortico-motoneuronal projections, Electroencephalogr Clin Neurophysiol, Vol. 81, p. 63
Study ID Numbers 98-N-0065
NLM Identifier NCT00001780
Date study startedFebruary 10, 1998
Record last reviewed November 16, 2000
Last Updated November 16, 2000