Wise Young
08-06-2001, 01:17 AM
http://clinicaltrials.gov/ct/gui/c/a1b/show/NCT00001364?order=11&JServSession Idzone_ct=zhn5b9gan1 (http://clinicaltrials.gov/ct/gui/c/a1b/show/NCT00001364?order=11&JServSessionIdzone_ct=zhn5b9gan1)
Evaluation and Treatment of Patients Spinal Blood Vessel Abnormalities
This study is currently recruiting patients.
Sponsored by
National Institute of Neurological Disorders and Stroke (NINDS)
Purpose
Arteriovenous malformations (AVM) are abnormally formed blood vessels that can be located throughout the brain and spinal cord. Patients with abnormalities of the blood vessels located in and around the spinal cord can develop many neurological problems. Some problems include, weakness, pain, difficulty walking, paralysis, and even death.
The treatment for these AVMs depends on their location, the type of malformation, the area of the spine involved, and the condition of the patient at the time of treatment. The treatment is aimed at stopping the neurologic problems from worsening and possibly correcting the existing problems. There are two commonly used treatments for AVMs, surgery and embolization (blocking off of blood flow to the AVM).
However, researchers have limited experience treating these conditions because they are rare. In addition, it has been difficult to classify different kinds of AVMs and to develop new treatments for them.
This study is designed to increase researchers understanding of AVMs by admitting and following patients diagnosed with the condition. By increasing the amount of patients studied diagnosed with spinal blood vessel abnormalities, researchers can begin to develop new management plans for patients with AVMs.
Condition
Arteriovenous Fistula
Arteriovenous Malformation
Spinal Cord Disease
MEDLINEplusrelated topics:BirthDefects; CirculatoryDisorders; SpinalCordDiseases
Study Type:Natural History
Official Title:Evaluation and Treatment of Patients with Spinal Vascular Abnormalities
Further Study Details:
Spinal Arteriovenous Malformations are rare lesions that frequently affect young patients and adults in their most productive years. They cause progressive myelopathy, ultimately causing paraplegia or quadriplegia if untreated. Because they are rare lesions, experience with treating them in sufficient numbers to permit classification of them, investigation of the pathophysiology of myelopathy, and the introduction of new techniques for treatment has been possible in only a very few centers in this country. One essential element of investigation of them is selective spinal arteriography. Since selective spinal arteriography was first introduced for these lesions here at the NIH in the mid 1960's by Drs. John Doppman and Giovanni DiChiro, the NIH has been such a center of expertise for patients with spinal arteriovenous malformations. Because of this, NIH has been, and is, a national referral center for these patients. However, there has never been an approved protocol at the NIH for investigation or treatment of these patients. The purpose of this proposal is to present a plan of investigation and treatment that will serve as a protocol under which to admit these patients and to permit continued accrual of clinical experience with them that will serve to guide others in the management of these patients.
Eligibility
Genders Eligible for Study: Both
Criteria
Patients suspected to have spinal arteriovenous malformations (AVM).
Location and Contact Information
Maryland
National Institute of Neurological Disorders and Stroke (NINDS),9000 Rockville Pike Bethesda, Maryland, 20892, United States;Recruiting
PRPL 1-800-411-1222 prpl@mail.cc.nih.gov
More Information
Detailed Web Page
Publications
McCutcheon. 1996. Microvascular anatomy of dural arteriovenous abnormalities of the spine: a microangiographic study, J Neurosurg, Vol. 84, p. 215
Afshar. 1995. Surgical interruption of intradural draining vein as curative treatment of spinal dural arteriovenous fistulas, J Neurosurg, Vol. 82, p. 196
Oldfield. 1988. Spinal arteriovenous malformations, Clin Neurosurg, Vol. 34, p. 161
Study ID Numbers 93-N-0151
NLM Identifier NCT00001364
Date study startedJune 2, 1993
Record last reviewed May 21, 2001
Last Updated May 21, 2001
[This message was edited by Wise Young on August 06, 2001 at 12:36 PM.]
Evaluation and Treatment of Patients Spinal Blood Vessel Abnormalities
This study is currently recruiting patients.
Sponsored by
National Institute of Neurological Disorders and Stroke (NINDS)
Purpose
Arteriovenous malformations (AVM) are abnormally formed blood vessels that can be located throughout the brain and spinal cord. Patients with abnormalities of the blood vessels located in and around the spinal cord can develop many neurological problems. Some problems include, weakness, pain, difficulty walking, paralysis, and even death.
The treatment for these AVMs depends on their location, the type of malformation, the area of the spine involved, and the condition of the patient at the time of treatment. The treatment is aimed at stopping the neurologic problems from worsening and possibly correcting the existing problems. There are two commonly used treatments for AVMs, surgery and embolization (blocking off of blood flow to the AVM).
However, researchers have limited experience treating these conditions because they are rare. In addition, it has been difficult to classify different kinds of AVMs and to develop new treatments for them.
This study is designed to increase researchers understanding of AVMs by admitting and following patients diagnosed with the condition. By increasing the amount of patients studied diagnosed with spinal blood vessel abnormalities, researchers can begin to develop new management plans for patients with AVMs.
Condition
Arteriovenous Fistula
Arteriovenous Malformation
Spinal Cord Disease
MEDLINEplusrelated topics:BirthDefects; CirculatoryDisorders; SpinalCordDiseases
Study Type:Natural History
Official Title:Evaluation and Treatment of Patients with Spinal Vascular Abnormalities
Further Study Details:
Spinal Arteriovenous Malformations are rare lesions that frequently affect young patients and adults in their most productive years. They cause progressive myelopathy, ultimately causing paraplegia or quadriplegia if untreated. Because they are rare lesions, experience with treating them in sufficient numbers to permit classification of them, investigation of the pathophysiology of myelopathy, and the introduction of new techniques for treatment has been possible in only a very few centers in this country. One essential element of investigation of them is selective spinal arteriography. Since selective spinal arteriography was first introduced for these lesions here at the NIH in the mid 1960's by Drs. John Doppman and Giovanni DiChiro, the NIH has been such a center of expertise for patients with spinal arteriovenous malformations. Because of this, NIH has been, and is, a national referral center for these patients. However, there has never been an approved protocol at the NIH for investigation or treatment of these patients. The purpose of this proposal is to present a plan of investigation and treatment that will serve as a protocol under which to admit these patients and to permit continued accrual of clinical experience with them that will serve to guide others in the management of these patients.
Eligibility
Genders Eligible for Study: Both
Criteria
Patients suspected to have spinal arteriovenous malformations (AVM).
Location and Contact Information
Maryland
National Institute of Neurological Disorders and Stroke (NINDS),9000 Rockville Pike Bethesda, Maryland, 20892, United States;Recruiting
PRPL 1-800-411-1222 prpl@mail.cc.nih.gov
More Information
Detailed Web Page
Publications
McCutcheon. 1996. Microvascular anatomy of dural arteriovenous abnormalities of the spine: a microangiographic study, J Neurosurg, Vol. 84, p. 215
Afshar. 1995. Surgical interruption of intradural draining vein as curative treatment of spinal dural arteriovenous fistulas, J Neurosurg, Vol. 82, p. 196
Oldfield. 1988. Spinal arteriovenous malformations, Clin Neurosurg, Vol. 34, p. 161
Study ID Numbers 93-N-0151
NLM Identifier NCT00001364
Date study startedJune 2, 1993
Record last reviewed May 21, 2001
Last Updated May 21, 2001
[This message was edited by Wise Young on August 06, 2001 at 12:36 PM.]