Nguyen, et al. (2002). Pre-existing pathways promote precise projection patterns.

[Wise Young]

• Nguyen QT, Sanes JR and Lichtman JW (2002). Pre-existing pathways promote precise projection patterns. Nat Neurosci 5:861-7. Summary: A large body of evidence shows that molecular cues promote specific synapse formation by guiding axons and by mediating their association with targets, but much less is known about the contribution of physical cues (such as mechanical constraints) to these processes. Here we used the peripheral motor system to investigate the latter issue. In living mice, we viewed individual motor axons bearing a fluorescent reporter, and mapped the cohort of muscle fibers that they innervated both before and after nerve damage. When gross trauma was minimized (by a nerve-crushing rather than nerve-cutting procedure), regenerating axons retraced their former pathways, bifurcated at original branch points, and formed neuromuscular junctions on the same fibers that they originally innervated. Axonal growth through tubes of non-neural cells seemed to account for this specificity, and specificity degraded when the tubes were cut. These results suggest that nonspecific guidance cues can be sufficient to generate specific synaptic circuitry. Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

[This message was edited by Wise Young on 06-11-03 at 10:32 AM.]

[Faye]

Hopefully this is also the case in the CNS once we can get the axons to grow.

[BeckysMom]

I am new to this website and hope I am posting in the proper place. I know this is a spinal injury website, but is anyone aware of stem cell transplants being done, anywhere, for traumatic brain injuries? I've been reading about the sci stem cell surgeries being done in China, Portugal and Australia, and wonder if anyone is doing this with TBI. My daughter has a severe TBI and I would like to find someone that can help her.

Thanks for any info-

Jana, Beckys Mom

[Wise Young]

Jana, there are studies of stem cell transplants into animal traumatic brain injury models. I do not know of any clinical trials that are going on in the United States or around the world right now transplanting stem cells into traumatically injured brain. There is, however, considerable research activity looking at the role of stem cells in stroke and even some clinical data regarding this from Diacrin (a company that is making pig fetal stem cells and funding clinical trials that are transplanting these cells into brains after stroke, Parkinson's disease, Huntington's disease, and spinal cord injury). If you have interest in this topic, I can post more information.

Wise.

[Acid]

"nonspecific guidance"

Didn't bother to read all the pervert stuff.
Also as it seemed magic systems in the parts I read, and partial correlations of these in hardware growth guidance, were in Westie style ignored.

(With magic control even interlinking can be generated non-natural routes to some extent, alike I did back then with Rob's hand.
Did the job, that since then he can feel into there to an extent again.
Before not for years since an accident.)

Magic systems, even if hardware is quite damaged or even gone, might still partially aim old routes.

But go on ignoring their importance.

[This message was edited by Acid on 11-02-03 at 05:49 PM.]

[Acid]

For mothers who wish to brainrape children with forcing stuff into the confiscated brain of the child, rumours have it, there's black labs in France who for enough cash might brain rape the kiddie with near any cancer danger hight cellular shit alien to the child's own gene codes.

Such criminal acts might be more committed in context with forms of autism or MBD forms, and at times the differing gened maybe being brain raped, but per se, I assume with enough cash, pretty much any child could be hauled for brain rape there, in case I got them rumours from sorts of the anti-autist-rumour-grape-vine correctly.

Seems more a financial question.

Not seriously, what the child got, or if the child slaves agree, whose brains do not seem regarded their's in the first place.

(But in case you expect I search my brain for where you might find hook-up to French black-labs, you might wait a long time.

I am absolutely against such criminal perversions.)