Wise Young
10-01-2001, 05:01 PM
http://www.nature.com/cgi-taf/DynaPage.taf?file=/nrn/journal/v2/n10/full/nrn1001-734a_fs.html
Nature Reviews Neuroscience 2, 734-744 (2001)
CYTOKINES AND ACUTE NEURODEGENERATION
Stuart M. Allan & Nancy J. Rothwell about the authors
School of Biological Sciences, University of Manchester, 1.124 Stopford Building,
Oxford Road, Manchester M13 9PT, UK.
Cytokines have been implicated as mediators and inhibitors of diverse
forms of neurodegeneration. They are induced in response to brain
injury and have diverse actions that can cause, exacerbate, mediate
and/or inhibit cellular injury and repair. Here we review evidence for
the contribution of cytokines to acute neurodegeneration, focusing
primarily on interleukin 1 (IL-1), tumour necrosis factor- (TNF) and
transforming growth factor- (TGF). TGF seems to exert primarily
neuroprotective actions, whereas TNF might contribute to neuronal
injury and exert protective effects. IL-1 mediates ischaemic,
excitotoxic and traumatic brain injury, probably through multiple
actions on glia, neurons and the vasculature. Understanding cytokine
action in acute neurodegeneration could lead to novel and effective
therapeutic strategies, some of which are already in clinical trials..
Nature Reviews Neuroscience 2, 734-744 (2001)
CYTOKINES AND ACUTE NEURODEGENERATION
Stuart M. Allan & Nancy J. Rothwell about the authors
School of Biological Sciences, University of Manchester, 1.124 Stopford Building,
Oxford Road, Manchester M13 9PT, UK.
Cytokines have been implicated as mediators and inhibitors of diverse
forms of neurodegeneration. They are induced in response to brain
injury and have diverse actions that can cause, exacerbate, mediate
and/or inhibit cellular injury and repair. Here we review evidence for
the contribution of cytokines to acute neurodegeneration, focusing
primarily on interleukin 1 (IL-1), tumour necrosis factor- (TNF) and
transforming growth factor- (TGF). TGF seems to exert primarily
neuroprotective actions, whereas TNF might contribute to neuronal
injury and exert protective effects. IL-1 mediates ischaemic,
excitotoxic and traumatic brain injury, probably through multiple
actions on glia, neurons and the vasculature. Understanding cytokine
action in acute neurodegeneration could lead to novel and effective
therapeutic strategies, some of which are already in clinical trials..