Wise Young
10-22-2001, 07:30 AM
Making methyl
22 October 2001 - J. Biol. Chem.
Methylation of DNA by the DNA methyltransferase enzyme at Cpg dinucleotide sequences is an important mechanism for the control of gene expression. Researchers found that interleukin (IL)-6 regulates the methyltransferase promoter. The results suggest that IL-6 and other inflammatory enzymes may act by regulating the expression of the methyltransferase gene. Similar activity may play a role in cell differentiation.
Reference: Hodge, D.R., Xiao, W., Clausen, P.A. et al. 2001. Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. J. Biol. Chem. 276(43):39508-39511.
22 October 2001 - J. Biol. Chem.
Methylation of DNA by the DNA methyltransferase enzyme at Cpg dinucleotide sequences is an important mechanism for the control of gene expression. Researchers found that interleukin (IL)-6 regulates the methyltransferase promoter. The results suggest that IL-6 and other inflammatory enzymes may act by regulating the expression of the methyltransferase gene. Similar activity may play a role in cell differentiation.
Reference: Hodge, D.R., Xiao, W., Clausen, P.A. et al. 2001. Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. J. Biol. Chem. 276(43):39508-39511.