Max
03-31-2003, 05:10 PM
EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing
Anna Aurora Battaglia, Karina Sehayek, John Grist, Stephen B. McMahon & Isabella Gavazzi
Centre for Neuroscience Research, King's College London, Guy's Campus, London SE1 1UL, UK
Correspondence should be addressed to I Gavazzi. e-mail: Isabella.Gavazzi@kcl.ac.uk
Eph receptor tyrosine kinases and their ephrin ligands are involved in crucial aspects of nervous system circuit assembly during development1, 2, but their functional roles in the mature nervous system are poorly understood. We investigated their role in pain processing, using a combination of immunohistochemical, behavioral, biochemical and primary cell culture techniques. Here we report an in vivo role for EphB-ephrinB interactions as modulators of synaptic efficacy in the spinal cord, contributing to sensory abnormalities in persistent pain states.
Anna Aurora Battaglia, Karina Sehayek, John Grist, Stephen B. McMahon & Isabella Gavazzi
Centre for Neuroscience Research, King's College London, Guy's Campus, London SE1 1UL, UK
Correspondence should be addressed to I Gavazzi. e-mail: Isabella.Gavazzi@kcl.ac.uk
Eph receptor tyrosine kinases and their ephrin ligands are involved in crucial aspects of nervous system circuit assembly during development1, 2, but their functional roles in the mature nervous system are poorly understood. We investigated their role in pain processing, using a combination of immunohistochemical, behavioral, biochemical and primary cell culture techniques. Here we report an in vivo role for EphB-ephrinB interactions as modulators of synaptic efficacy in the spinal cord, contributing to sensory abnormalities in persistent pain states.