Max
08-21-2002, 03:31 PM
link (http://www.docguide.com/news/content.nsf/PaperFrameSet?OpenForm&id=D039FAB5A22EA93A852569F3005A3774&c=&newsid=8525697700573E1885256BDD006CB42F&u=http://www.ingenta.com/isis/searching/ExpandTOC/ingenta?issue=infobike://npg/13624393/2002/00000040/00000006&index=5&WebLogicSession=PRDdqRAY0ApSBTlwzRIB|3209696930216 431820/-1052814329/6/7051/7051/7052/7052/7051/-1&ref=/news/content.nsf/SearchResults?openform&Query=spinal%20cord%20injury&so=date&id=D039FAB5A22EA93A852569F3005A3774)
Spinal Cord, June 2002, vol. 40, no. 6, pp. 282-285(4)
To T-P.[1]; Lim T.C.[2][3]; Hill S.T.[2]; Frauman A.G.[4]; Cooper N.[2]; Kirsa S.W.[1]; Brown D.J.[2]; Correspondence: T-P To*
[1]Pharmacy Department, Austin & Repatriation Medical Centre, Victoria, Australia [2]Victorian Spinal Cord Service, Austin & Repatriation Medical Centre, Victoria, Australia [3]Olympia Private Rehabilitation Hospital, Victoria, Australia [4]Clinical Pharmacology & Therapeutic, Austin & Repatriation Medical Centre, Victoria, Australia <LI>Pharmacy Department, Austin & Repatriation Medical Centre, Locked bag 25, Heidelberg, Vic. 3084, Australia; E-mail: phung@armc.org.au
Abstract:
Study design: Retrospective review of patient data.
Objective: To present two years of experience in the use of gabapentin for the alleviation of neuropathic pain in spinal cord injury patients.
Setting: Supra-regional Spinal Cord Service, Melbourne, Australia.
Method: Data were retrieved from the medical records of all spinal cord injury patients prescribed gabapentin for neuropathic pain. Pain was assessed prior to and during treatment at 1, 3 and 6 months with a 10 cm visual analogue scale which ranged from 0 ('no pain') to 10 ('worst pain imaginable'), or by the documentation of a verbal description of pain.
Results: Seventy-six per cent of patients receiving gabapentin reported a reduction in neuropathic pain. In those patients with data at all four measurement points, the mean pretreatment score was 8.86. Following treatment with gabapentin the score dropped to 5.23, 4.59 and 4.13 at 1, 3 and 6 months, respectively. Where only a verbal description of pain was documented, the trend was that the pretreatment report of 'unbearable' was replaced by 'liveable' during treatment.
Conclusion: Our experience suggests that gabapentin offers an effective therapeutic alternative for the alleviation of neuropathic pain following spinal cord injury. Controlled clinical trials are now required to confirm these observations.
Spinal Cord (2002) 40, 282-285 doi:10.1038/sj.sc.3101300
Language: English Document Type: Original article ISSN: 1362-4393
SICI (online): 1362-4393406282285
Publisher: Nature Publishing Group
==============================
"With every scientific advance, we grow closer to unlocking the mysteries of life and creation. But what have we gained if in the process, we lose our humanity. The most powerful thing we pass along to our children may not reside in the genes, but in the soul."
The Outer Limits(Criminal Nature)
[This message was edited by Wise Young on Aug 23, 2002 at 10:10 PM.]
Spinal Cord, June 2002, vol. 40, no. 6, pp. 282-285(4)
To T-P.[1]; Lim T.C.[2][3]; Hill S.T.[2]; Frauman A.G.[4]; Cooper N.[2]; Kirsa S.W.[1]; Brown D.J.[2]; Correspondence: T-P To*
[1]Pharmacy Department, Austin & Repatriation Medical Centre, Victoria, Australia [2]Victorian Spinal Cord Service, Austin & Repatriation Medical Centre, Victoria, Australia [3]Olympia Private Rehabilitation Hospital, Victoria, Australia [4]Clinical Pharmacology & Therapeutic, Austin & Repatriation Medical Centre, Victoria, Australia <LI>Pharmacy Department, Austin & Repatriation Medical Centre, Locked bag 25, Heidelberg, Vic. 3084, Australia; E-mail: phung@armc.org.au
Abstract:
Study design: Retrospective review of patient data.
Objective: To present two years of experience in the use of gabapentin for the alleviation of neuropathic pain in spinal cord injury patients.
Setting: Supra-regional Spinal Cord Service, Melbourne, Australia.
Method: Data were retrieved from the medical records of all spinal cord injury patients prescribed gabapentin for neuropathic pain. Pain was assessed prior to and during treatment at 1, 3 and 6 months with a 10 cm visual analogue scale which ranged from 0 ('no pain') to 10 ('worst pain imaginable'), or by the documentation of a verbal description of pain.
Results: Seventy-six per cent of patients receiving gabapentin reported a reduction in neuropathic pain. In those patients with data at all four measurement points, the mean pretreatment score was 8.86. Following treatment with gabapentin the score dropped to 5.23, 4.59 and 4.13 at 1, 3 and 6 months, respectively. Where only a verbal description of pain was documented, the trend was that the pretreatment report of 'unbearable' was replaced by 'liveable' during treatment.
Conclusion: Our experience suggests that gabapentin offers an effective therapeutic alternative for the alleviation of neuropathic pain following spinal cord injury. Controlled clinical trials are now required to confirm these observations.
Spinal Cord (2002) 40, 282-285 doi:10.1038/sj.sc.3101300
Language: English Document Type: Original article ISSN: 1362-4393
SICI (online): 1362-4393406282285
Publisher: Nature Publishing Group
==============================
"With every scientific advance, we grow closer to unlocking the mysteries of life and creation. But what have we gained if in the process, we lose our humanity. The most powerful thing we pass along to our children may not reside in the genes, but in the soul."
The Outer Limits(Criminal Nature)
[This message was edited by Wise Young on Aug 23, 2002 at 10:10 PM.]