View Full Version : Neurosurgery (2002). Pharmacological therapy after acute cervical spinal cord injury.
Wise Young
11-24-2002, 10:34 PM
• (2002). Pharmacological therapy after acute cervical spinal cord injury. Neurosurgery 50:S63-72. Summary: CORTICOSTEROIDS: Standards: There is insufficient evidence to support treatment standards. Guidelines: There is insufficient evidence to support treatment guidelines. Options: Treatment with methylprednisolone for either 24 or 48 hours is recommended as an option in the treatment of patients with acute spinal cord injuries that should be undertaken only with the knowledge that the evidence suggesting harmful side effects is more consistent than any suggestion of clinical benefit. GM-1 GANGLIOSIDE: Standards: There is insufficient evidence to support treatment standards. Guidelines: There is insufficient evidence to support treatment guidelines. Options: Treatment of patients with acute spinal cord injuries with GM-1 ganglioside is recommended as an option without demonstrated clinical benefit.
"Treatment with methylprednisolone...should be undertaken only with the knowledge that the evidence suggesting harmful side effects is more consistent than any suggestion of clinical benefit."
Dr. Young how do you feel when you hear shit like this?
I feel like someone kicked me right in the testicles... (pre injury of course).
I can clearly see a day in the future when acute injuries can be healed and these same dinosaurs simply REFUSE to do it and nonchalantly say "The CNS can't heal. I don't believe this regeneration hocus pocus so I am not going to even try and therefore you will never walk again" When will these dinosaurs finally die?
Wise Young
11-28-2002, 10:35 PM
Mike, I learned a very important lesson from methylprednisolone. Good science is not enough. A treatment is used only when you can win the hearts and minds of the clinicians. We did not do that right with methylprednisolone and this continues to haunt us. Wise.
jway2002
11-29-2002, 12:34 AM
Dr. Young, as you know, administration of MP is not considered standard in Canada. I was wondering if one could insist on MP upon admittance after a SCI? (Not so much the patient as maybe a parent or other advocate)
My son was operated on, seven days after his injury. In your opinion, would MP have had an effect on his recovery? Thanks