Wise Young
06-22-2003, 07:40 AM
• Gharavi AE and Pierangeli SS (1998). Origin of antiphospholipid antibodies: induction of aPL by viral peptides. Lupus 7 Suppl 2:S52-4. Summary: The clinical associations of antiphospholipid antibodies (aPL) are well recognized but the mechanism(s) causing the production of these antibodies are not yet known. We demonstrated the induction of pathogenic aPL antibodies that caused intrauterine fetal death and transverse myelopathy due to spinal cord infarction in mice by immunization with foreign beta2GPI. We also induced aPL and anti-beta2-GPI in mice by immunization with PL-binding viral peptides and hypothesized that in APS patients, aPL may be induced by beta2GPI-like-PL-binding products of common human bacteria and viruses. Morehouse School of Medicine, Department of Medicine, Atlanta, GA 30310-1495, USA. AGHARA@POL.NET
Wise Young
06-22-2003, 07:43 AM
• Gharavi AE, Pierangeli SS and Harris EN (2000). New developments in viral peptides and APL induction. J Autoimmun 15:227-30. Summary: The associations of antiphospholipid antibodies (aPL) with thrombosis and fetal death are well recognized, but the mechanism(s) that induce their production are not. We demonstrated induction of pathogenic aPL antibodies by immunization with foreign beta(2)-GPI, or synthetic peptides representing the PL-binding site of the beta(2)-GPI. These antibodies caused intrauterine fetal death and transverse myelopathy due to spinal cord infarction in mice, and activated endothelial cells in vitro. We also introduced aPL in mice by immunization with PL-binding viral peptides and observed their pathogenic effects. This study demonstrated that pathogenic effects of aPL antibodies induced by immunization with a human CMV-derived PL-binding synthetic peptide. We hypothesize that in APS patients aPL is induced by beta(2)-GPL-like PL-binding products of human common bacteria or viruses. Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA. aghara@pol.net