Stem cell treatment improves mobility after spinal cord injury

[Max]

Stem cell treatment improves mobility after spinal cord injury
11 May 2005





A treatment derived from human embryonic stem cells improves mobility in rats with spinal cord injuries, providing the first physical evidence that the therapeutic use of these cells can help restore motor skills lost from acute spinal cord tissue damage.

Hans Keirstead and his colleagues in the Reeve-Irvine Research Center at UC Irvine have found that a human embryonic stem cell-derived treatment they developed was successful in restoring the insulation tissue for neurons in rats treated seven days after the initial injury, which led to a recovery of motor skills. But the same treatment did not work on rats that had been injured for 10 months. The findings point to the potential of using stem cell-derived therapies for treatment of spinal cord damage in humans during the very early stages of the injury. The study appears in the May 11 issue of The Journal of Neuroscience.
http://www.medicalnewstoday.com/medicalnews.php?newsid=24159



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[okwjoe]

Dang.. Only acutes will benefit..

[Steven Edwards]

Joe, the inhibitors presented by "scar" tissue have been overcome with some combination therapies . Keirstead's group may be working to combine this with something like chondroitinase to overcome the "scar" problem and allow this to work in chronics.

-Steven
...[I]how did it end up like this? it was only a kiss, it was only a kiss.

[Rollin Rick]

Acute this, acute that, it's getting old. How about a cute girl? That'll help being in my chronic condition. http://sci.rutgers.edu/forum/images/smilies/smile.gif

[Max]

Stem cell treatment improves mobility after spinal cord injury
Filed under: Genetics



Interesting results are reported from the Reeve-Irvine Research Center at UC Irvine:

A treatment derived from human embryonic stem cells improves mobility in rats with spinal cord injuries, providing the first physical evidence that the therapeutic use of these cells can help restore motor skills lost from acute spinal cord tissue damage.
Hans Keirstead and his colleagues in the Reeve-Irvine Research Center at UC Irvine have found that a human embryonic stem cell-derived treatment they developed was successful in restoring the insulation tissue for neurons in rats treated seven days after the initial injury, which led to a recovery of motor skills. But the same treatment did not work on rats that had been injured for 10 months. The findings point to the potential of using stem cell-derived therapies for treatment of spinal cord damage in humans during the very early stages of the injury. The study appears
http://www.medgadget.com/archives/2005/05/stem_cell_treat.html



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[vienna]

from the same article (http://www.medgadget.com/archives/2005/05/stem_cell_treat.html)


"...Keirstead and his colleagues are currently working on other approaches using human embryonic stem cells to treat chronic injuries and other disorders of the central nervous system."

[Steven Edwards]

This may be Keirstead's work from two years ago, meaning he's probably further along than what's presented here.

-Steven
...how did it end up like this? it was only a kiss, it was only a kiss.

[Schmeky]

This study suggests one approach to treating people who've just suffered spinal cord injury, although there is still much work to do before we can engage in human clinical tests."
How may approaches that work do we need?

I "love" the urgency song Kierstad has been singin', but the lericks above sound like a familiar tune.

This is good news, I wonder if anyone can positively acknowledge his human clinical trial schedule suggested by other members (sometime in 2006 for acutes)?

Please forgive me, but how can Reeve-Irvine, which is about 10 years old, be so (seemingly) far ahead of the Miami Project (nearly 20 years old)? Or am I wrong?