wildwilly
01-31-2009, 08:31 PM
Neurochem Res. 2009 Jan 24.
Protective Effect of Granulocyte Colony-stimulating Factor on Intracerebral Hemorrhage in Rat.
Zhang L, Shu XJ, Zhou HY, Liu W, Chen Y, Wang CL, Li Y, Chen QX, Liu LJ, Wang JZ.
Hubei Provincial Key Laboratory of Neurological Disease, Pathophysiology Department, Tongji Medical College, Hua-Zhong University of Science and Technology, 430030, Wuhan, People's Republic of China.
Granulocyte colony-stimulating factor (G-CSF) is a member of the cytokine family of growth factors that can protect the neurons from focal cerebral ischemia-induced injuries. The intracerebral hemorrhage (ICH) has been widely observed in the clinic; however, the protective effect of G-CSF on ICH is still elusive. We found in the present study that the intraperitoneal injection of G-CSF for 5 days could improve the ICH-induced neuronal behavioral impairment measured by limb placement assay. We also observed that injection of G-CSF could increase the number of stem cells in the specific zone of the hemorrhagic areas, demonstrated by the enhanced expression of nestin. Additionally, G-CSF could also promote the mobilization of circulating hemopoietic stem cells (HSCs) to the damaged brain areas and activate the astrocytes. Our results reveal that G-CSF is also protective for the ICH with the mechanisms involving proliferation of neural stem cells, the migration of HSCs and the activation of astrocytes.
http://www.ncbi.nlm.nih.gov/pubmed/19169816?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Protective Effect of Granulocyte Colony-stimulating Factor on Intracerebral Hemorrhage in Rat.
Zhang L, Shu XJ, Zhou HY, Liu W, Chen Y, Wang CL, Li Y, Chen QX, Liu LJ, Wang JZ.
Hubei Provincial Key Laboratory of Neurological Disease, Pathophysiology Department, Tongji Medical College, Hua-Zhong University of Science and Technology, 430030, Wuhan, People's Republic of China.
Granulocyte colony-stimulating factor (G-CSF) is a member of the cytokine family of growth factors that can protect the neurons from focal cerebral ischemia-induced injuries. The intracerebral hemorrhage (ICH) has been widely observed in the clinic; however, the protective effect of G-CSF on ICH is still elusive. We found in the present study that the intraperitoneal injection of G-CSF for 5 days could improve the ICH-induced neuronal behavioral impairment measured by limb placement assay. We also observed that injection of G-CSF could increase the number of stem cells in the specific zone of the hemorrhagic areas, demonstrated by the enhanced expression of nestin. Additionally, G-CSF could also promote the mobilization of circulating hemopoietic stem cells (HSCs) to the damaged brain areas and activate the astrocytes. Our results reveal that G-CSF is also protective for the ICH with the mechanisms involving proliferation of neural stem cells, the migration of HSCs and the activation of astrocytes.
http://www.ncbi.nlm.nih.gov/pubmed/19169816?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum